Type I collagen fibrils: an inducer of invadosomes
نویسندگان
چکیده
منابع مشابه
Type I collagen fibrils: an inducer of invadosomes
Cell-extracellular matrix (ECM) interaction controls a multitude of biological and cellular processes such as adhesion, migration, invasion, gene activation, differentiation and proliferation. ECM constitutes a complex and dynamic structure; indeed there are a lot of molecular components able to participate to the ECM formation. We could notably mention collagens, laminins or vitronectin. The E...
متن کاملType I collagen fibrils and discoidin domain receptor 1 set invadosomes straight
Accumulation of type I collagen fibrils in tumors is associated with an increased risk of metastasis. We recently demonstrated that the collagen sensor discoidin domain receptor 1 (DDR1) interacts with type I collagen fibrils to allow proteolysis-based cancer cell invasion through the formation of a new class of invadosomes, termed linear invadosomes.
متن کاملThermal (in)stability of type I collagen fibrils.
We measured the Young's modulus at temperatures ranging from 20 to 100 degrees C for a collagen fibril that is taken from a rat's tendon. The hydration change under heating and the damping decrement were measured as well. At physiological temperatures 25 to 45 degrees C, the Young's modulus decreases, which can be interpreted as an instability of the collagen. For temperatures between 45 and 80...
متن کاملIntegrin-mediated cell adhesion to type I collagen fibrils.
In the integrin family, the collagen receptors form a structurally and functionally distinct subgroup. Two members of this subgroup, alpha(1)beta(1) and alpha(2)beta(1) integrins, are known to bind to monomeric form of type I collagen. However, in tissues type I collagen monomers are organized into large fibrils immediately after they are released from cells. Here, we studied collagen fibril re...
متن کاملStructural investigations on native collagen type I fibrils using AFM.
This study was carried out to determine the elastic properties of single collagen type I fibrils with the use of atomic force microscopy (AFM). Native collagen fibrils were formed by self-assembly in vitro characterized with the AFM. To confirm the inner assembly of the collagen fibrils, the AFM was used as a microdissection tool. Native collagen type I fibrils were dissected and the inner core...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.5804